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Shared Neurobiology of Fragile X Syndrome and Autism

Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - May 12, 2005
Applications Due:

Multiple Receipt Dates - See Link to Full Announcement for details.

total funding: Not Available
max award: none
min award: none
cost sharing, matching: No
number of awards: Not Available
type of funding: Grant

The National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Child Health and Human Development (NICHD) have entered into a public-private partnership with the Canadian Institutes of Health Research (CIHR), the Health Research Board, Ireland (HRB), Cure Autism Now (CAN), the National Alliance for Autism Research (NAAR), Autism Speaks and the FRAXA Research Foundation (FRAXA) to jointly sponsor this Program Announcement (PA), which is aimed at characterizing, understanding and treating etiological and pathophysiological mechanisms common to both Fragile X syndrome (FXS) and autism (including autism spectrum disorders such as Rett syndrome). Between 2.5 percent and 6 percent of individuals with autistic feature have FXS, and approximately 15 percent to 25 percent of children with FXS have autism. An additional 50 percent to 90 percent of children with FXS exhibit some sympto!
ms and features associated with autism, including poor eye contact, hand flapping, hand biting, speech perseveration and other language abnormalities and problems, as well as tactile defensiveness, mental retardation in the moderate to severe range, developmental delay, sensory hyperarousal, and social anxiety with mood liability. Researchers have argued that autism and autistic symptoms in FXS reflect a common etiological or pathophysiological pathway underlying the two conditions. Ongoing basic neuroscience research on FXS in model systems like the mouse and fly are providing a wealth of information at multiple levels subcellular, cellular, and intercellular networks or circuits to delineate the neurobiology of this disorder. These studies should dissect components of the neurobiology of autism, especially in patients with both FXS and autism, and identify novel targets for new drugs to treat both disorders. Applications submitted in response to this PA should focus o!
n a topic related to understanding neural pathways, circuits, systems
and molecules that play a role in the etiology or pathophysiology of FXS and may be implicated in autism (including autism spectrum disorders such as Rett syndrome). Studies emphasizing the identification of drug targets for new therapeutic drugs to treat FXS and autism are particularly encouraged. Research projects supported under this PA that include human subjects should include children affected with both FXS and autism and animal studies may include several models systems, e.g., mouse, fly and zebrafish. Basic neuroscience research in model systems should focus on both FXS and autism. Research more exclusively focused on autism that would not be covered under this PA may be submitted under PA-04-085 (see http://grants.nih.gov/grants/guide/pa-files/PA-04-085.html).

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Extramural Research Programs in the Neurosciences and Neurological Disorders
Mental Health Research Grants
National Institute of Child Health and Human Development Extramural Research

More Information:


If you have problems accessing the full announcement, please contact: NIH OER Webmaster

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